A virus that was created for the purpose of battling cancer and it's administered to those with cancer and it looked promising. But a few years later it would mutate into plague that kills most of the people on earth or turns them into creatures, There are a few who are immune. Among them is military scientist, Robert Neville who has spent the last three years after the plague decimated humanity trying to find a cure. But he is losing hope until two others who are also immune show up.

James Newton Howard (The Green Lantern, Signs) who is no stranger to the sci-fi element adds an extra ingredient into an already fun ride at the movies.